Edonerpic maleate is a novel neurotrophic agent that can inhibit amyloid-β peptides (Aβ). It is intended for research use only and is not sold to patients. In vitro, it preserves cortical neurons in the presence of Aβ(1-42), prevents oxidative stress-induced neuronal death, and promotes neurite outgrowth. In vivo, it ameliorates deficits in adult neurogenesis and spatial memory.
- Novel neurotrophic agent
- Inhibits amyloid-β peptides (Aβ)
- In vitro efficacy: preserves cortical neurons
- Prevents oxidative stress-induced neuronal death
- Promotes neurite outgrowth
- In vivo efficacy: ameliorates deficits in adult neurogenesis and spatial memory